Nova is a psychotic scientist and a genius. Through the series Nova acts as both a foe and an ally of Alita, as he isn't loyal to anyone and has his research as the highest priority. Nova is obsessed with the desert dish; Flan.

Sieg is a Knight of the Dark Glyphs. He is able to sacrifice lost souls in order to summon creatures called Chaos Legions from alternate worlds. Sieg is selected by The Order of St. Overia to track down his former friend Delacroix, and put a stop to his actions.

Zero is a high ranked Maverick Hunter in the Megaman X series, and a legendary freedom fighter in the Megaman Zero series. He is a skilled swordfighter, who does not hesitate to take action. However, behind his cold and emotionless attitude lies a wounded soul.

The Black Knight is the most powerful general of Daein. His true identity is Zelgius, the greatest general of the Begnion Empire. Both as Zelgius and The Black Knight, he serves Prime Minister Sephiran, who provided him with the blessed twin swords Alondite and Ragnell, and the blessed black armor he wears as The Black Knight.